Chapter 27—osteoporosis and Osteomalacia

Chapter 1 Ambulatory office practice Osteoporosis Tamara

Osteoporosis is asymptomatic until a fracture occurs; making the diagnosis and initiating treatment in the presymptomatic stage may prevent fractures. Measurement of bone mineral density (BMD) is a good but not perfect predictor of fractures. Introduction of the FRAX tool, which combines clinical risk factors and BMD, has improved assessment of fracture risk and therapeutic decision making. Sec...

Clinical, biochemical, and histological studies of osteomalacia, osteoporosis, and parathyroid function in chronic liver disease.

Twenty of 32 patients with either chronic cholestatic or hepatocellular liver disease had bone pain or recent fractures. On bone biopsy five patients had normal bone, 15 had osteomalacia, five had osteoporosis, and seven had a combination of osteomalacia and osteoporosis. In the presence of osteoporosis, osteomalacia was minimal or absent. There was no biochemical, radiological, or histological...

The Study of Osteoporosis and Osteomalacia.

Osteomalacia and osteoporosis: evaluation of a diagnostic index.

Data from a retrospective study in 41 patients is used to suggest an index of bone disease. This is designed as a means of collating available results, clarifying the significance of each in diagnosing either osteomalacia or osteoporosis, and reducing the significance of a single abnormal finding--for example, a raised alkaline phosphatase activity or low serum 25 hydroxy vitamin D, when the ov...

Determining Osteoporotic Tendencies from Tissue Mineral Analysis of Human Hair Type I and Type Ii

Osteoporosis is characterized by abnormal porosity and rarefaction of bone, resulting in decreased radiodensity. Albright defined osteoporosis as: "that category of decreased bone mass where the disturbance is the failure of the osteoblast to lay down bone matrix." He further stated that "Osteoporosis is a decreased production of osteoid by the osteoblasts, and is a defect in tissue metabolism....